泌尿器科領域におけるCefpiromeの使用経験

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  • CEFPIROME IN URINARY TRACT INFECTIONS

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We evaluated a newly developed cephem antibiotic, cefpirome (CPR), for its clinical efficacy and safety in 12 cases of chronic complicated cystitis, 6 cases of chronic complicated pyelonephritis and 3 cases of post-prostatectomy infection.<BR>The drug was administered i.v. or by d.i. in a daily dose of 1.0 g or 2.0 g for 5 days Clinical efficacy, evaluated according to the criteria proposed by the Japanese UTI Committee (3rd ed.), was excellent in 3, moderate in 11 and poor in 3 of 17 patients with chronic complicated UTI. The overall efficacy rate was 82.4%.<BR>Bacteriologically, 27 of 31 strains (87.1%) isolated from chronic complicated UTI were eradicated after CPR treatment.<BR>No adverse reactions occurred in any of the cases. In laboratory examinations, abnormal values were observed in I of 21 cases (slight elevation of S-creatinine).

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