産婦人科領域におけるbiapenemの基礎的・臨床的検討
書誌事項
- タイトル別名
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- Pharmacokinetic and clinical study of biapenem in obstetric and gynecology
抄録
Biapenem (BIPM) is a new 4 α-methyl carbapenem antibiotic with an exceptionally broad spectrum of an antibacterial activity in vitro and is stable to human renal dehydropeptidase-I (DHP-I).<BR>Pharmacokinetic and clinical studies of BIPM, a newly carbapenem compound were performed.<BR>The intravenously administered BIPM, a single drip infusion (60min) of 300mg, showed the fast and good penetration to the tissues (cervix uteri, portio vaginalis, myometrium, endometrium, oviduct and ovary): the peak concentration in the elbow vein and uterine artery were 6.9 and 6.3 μg/ml, respectively. Maximum concentrations in genital tissues were 1.6-4.5μg/g.<BR>BIPM was administered to 5 patients, 2 with puerperal intrauterine infection, 1 with uterine adnexitis and 2 with pelvicperitonitis at a dose of 300mg, 2 or 3 times for 6 to 10 days.<BR>As a result, the clinical effects of BIPM were good in all cases. Two strains Escherichia coli and Klebsiella pneumoniae, were eradicated after treatment. Neither side effects nor abnormal laboratory test values were observed. Ultimately, BIPM were very useful for gynecologic infections.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 42 (Supplement4), 602-607, 1994
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206284889216
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- NII論文ID
- 130004198765
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- ISSN
- 18845894
- 00093165
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可