黄体形成ホルモン放出ホルモンおよびその高活性アナログの抗原性

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  • 山崎 巖
    武田薬品工業株式会社中央研究所医薬研究所

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タイトル別名
  • Studies on the antigenicity of luteinizing hor-mone-releasing hormone (LH-RH) and its potent analogues
  • オウタイ ケイセイ ホルモン ホウシュツ ホルモン LH RH オヨビ ソノ

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抄録

Antigenicity of luteinizing hormone-releasing hormone (LH-RH) and its potent analogues des-Gly10-LH-RH-ethylamide (analogue I) and des-Gly10-[D-Leu6]-LH-RH-ethylamide (analogue II) was studied by means of the active anaphylactic and passive cutaneous anaphylactic (PCA) tests.<BR>In the active anaphylactic test using gninea pigs, sensitized animls with LH-RH, analogues I and II showed mild reactions similar to the anaphylactic symptoms (hyperemia of ear lappet, shiver-ing, urination or defecation) when the corresponding compounds were challenged, but the same reactions were equally observed with these compounds in unsensitized intact animals. Thus, it is concluded that the reactions were not induced by antibodies produced but by the inherent disposi-tions of these compounds.<BR>In the PCA test, two rabbits for the respective compounds were sensitized by eight repeating intradermal and intramuscular injections, and one intravenous booster injection with these compounds. PCA reactions were examined in guinea pigs for the sera thus obtained. Both of the sera prepared by the LH-RH injection produced a moderate PCA reaction. One serum prepared by analogue I produced a false positive, but the other showed no reaction. Neither of the sera by analogue II produced the reaction.

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