Basal and Calcium-stimulated Serum Calcitonin Levels in Chronic Hypergiucocorticoid Subjects

• SUZUKI Koyasu

  Second Department of Internal Medicine

• KONO Norio

  Second Department of Internal Medicine

• HAZAMA Takanori

  Second Department of Internal Medicine

• NAKAMURA Yusaku

  Second Department of Internal Medicine

• SOGA Fumihisa

  Second Department of Internal Medicine

• KAWACHI Masanori

  Second Department of Internal Medicine

• AKANEYA Yukio

  Second Department of Internal Medicine

• ONISHI Toshio

  Department of Medicine and Geriatrics, Osaka University Medical School

• TAKAHASHI Mitsuo

  Second Department of Internal Medicine

• MORIWAKI Kaname

  Second Department of Internal Medicine

• TARUI Seiichiro

  Second Department of Internal Medicine

抄録

To investigate the C-cell function (parafollicular cells of the thyroids) in chronic hyperglucocorticoid subjects, calcium infusion test was performed to six hyerglucocorticoid subjects and eleven age-and-sex matched normal controls. The secondary hyerparathyroidism developed in the chronic hyperglucocorticoid subjects. Basal levels of serum calcitonin and the maximum increments in serum calcitonin levels after the intravenous infusion of 3mg of calcium/kg of body weight over 10 minutes were not significantly different between these two groups. Our results indicate that the C-cell function, as estimated by the calcitonin response to calcium infusion, was not impaired in the chronic hyerlucocorticoid subjects. Therefore, calcitonin may not play a critical role in the pathogenesis of glucocorticoid-induced bone loss.

収録刊行物

• 日本骨代謝学会雑誌

  日本骨代謝学会雑誌 4 (3), 173-177, 1986

  日本骨代謝学会

詳細情報

• CRID: 1390282679615538816
• NII論文ID: 130004243632
• DOI: 10.11393/jbmm1983.4.173
• ISSN: 18849210
• ISSN: 09100067
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可