高カルシウム血症, 腎石灰化, 硬化性糸球体腎炎を伴ったサルコイドーシスの一例

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  • A Case of Sarcoidosis with Hypercalcemia, Renal Calcification and Sclerosing Glomerulonephritits

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A 57-year-old Japanese man was admitted to Sapporo medical university hospital because of hypercalcemia and renal dysfunction. Laboratory data disclosed elevated levels of serum and urine calcium and serum 1, 25(OH)2D3. Radiological examinations showed bilateral hiliar lymphangiopathy and renal stones. Histopathological findings of the lung and mediastinal lymph nodes biopsy specimens showed non-caseating epithelioid cell granulomas. Histopathological findings of the renal biopsy specimens were sclerosing glomerulonephritis and deposits of calcium crystal in renal tubules. Renal dysfunction improved with corticosteroid therapy, in parallel with decrease in serum 1, 25(OH)2D3 and serum calcium level. We reviewed reports on sarcoidosis with renal involvement.

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