THE ACTIONS OF SULFONAMIDE COMPOUNDS AND p-AMINOBENZOIC ACID ON THE VIRUS OF LYMPHOGRANULOMA INGUINALE AND TYPHUS RICKETTSIAE IN VITRO*

• TAKEMORI NOBUYUKI

  The Hygienic Institute

書誌事項

タイトル別名

• THE ACTIONS OF SULFONAMIDE COMPOUNDS AND <I>p</I>-AMINOBENZOIC ACID ON THE VIRUS OF LYMPHOGRANULOMA INGUINALE AND TYPHUS RICKETTSIAE IN VITRO<SUP>*</SUP>

抄録

In 1940 Woods and Fildes (1) showed that p-aminobenzoic acid was able to inhibit the action of sulfanilamide on the growth of haemolytic streptococci in vitro. Since then the anti-sulfonamide activity of p-aminobenzoic acid was demonstrated in several species of bacteria both in vitro and in the animal body. For instance, Selbie (2) showed that p-aminobenzoic acid, administered by mouth, could inhibit the curative action, of sulfanilamide in experimental infections of mice with group A haemolytic streptococci. Findlay (3) confirmed the same inhibitory action following both intracerebral and intraperitoneal inoculation of haemolytic streptococci in mice. Rubbo and Gillespie (4) showed that p-aminobenzoic acid inhibited the bacteriostatic action of sulfanilamide on Clostridium acetobutylicum. Landy and Wyeno (5) reported experiments which demonstrated that p-aminobenzoic acid was capable of inhibiting the effect of sulfonamide drugs on the growth of streptococci, pneumococci and staphylococci in vitro. Strauss, Dingle and Finland (6) showed that p-aminobenzoic acid inhibited the anti-bacterial activity of sulfathiazole on pneumococci. McCarty (7) reported that p-aminobenzoic acid (given subcutaneously) was found capable of nullifying the curative effect of sulfapyridine (given peros) for type I pneumococcus infection in mice. Kimming (8) showed that the effect of sulfonamide compounds on gonococci in vitro was reversed by p-aminobenzoic acid. Kuhn, Möller and Wend (9) showed that p-aminobenzoic acid could interfere with the bacteriostatic action of sulfonamide compounds on streptobacterium plantarum.<BR>On the other hand, in the case of the sulfonamide-sensitive viruses, Findlay (3) showed for the first time that p-aminobenzoic acid could inhibit the chemotherapeutic action of sulfanilamide on the virus of lymphogranuloma veiereum injected intracerebrally in mice. It appeared to be of interest to determine whether the chemotherapeutic action of the sulfonamide group of drugs on this virus was also inhibited in ti. vitro growth tests by p-aminobenzoic acid.<BR>In viruses and rickettsiae, however, in vitro growth tests can be undertaken only by means of tissue culture method. In former studies (10) we showed that the virus of lymphogranulomaa venereum and typhus rickettsiae could be grown in deep columns of Maitland medium and their growth could be examined easily under microscope. Therefore, in the present study, the method of cultivation in deep columns of Maitland medium was used to test the actions of sulfonamide compounds and p-aminobenzoic acid on the virus of lymphogranuloma inguinale and typhus rickettsiae in vitro.<BR>In the present paper the inhibition by p-aminobenzoic acid of the chemotherapeutic activity of sulfonamide drugs on the virus of lymphogranuloma inguinale in vitro is described. Furthermore, it is shown that p-aminobenzoic acid inhibits the growth of typhus rickettsiae in vitro, while sulfonamide compounds have no inhibiting effect on the growth of rickettsiae.

収録刊行物

• Ｔｈｅ　Ｊａｐａｎｅｓｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ

  Ｔｈｅ　Ｊａｐａｎｅｓｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ 2 (1), 1-8, 1949

  国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

詳細情報

• CRID: 1390001205387348480
• NII論文ID: 130004296996
• DOI: 10.7883/yoken1948.2.1
• ISSN: 1884281X
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可