歯性感染症から分離したＰｒｅｖｏｔｅｌｌａ　ｉｎｔｅｒｍｅｄｉａのβ‐ｌａｃｔａｍ薬感受性とβ‐ｌａｃｔａｍａｓｅ活性

DOI 被引用文献5件 参考文献18件

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  • Susceptibility of Prevotella intermedia isolated from odontogenic infection to .BETA.-lactam antibiotics, and .BETA.-lactamase activity.

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The MICs of antibiotics against Prevotella intermedia which were predominantly isolated from closed abscesses or cellulitis, and β-lactamase activity were measured to determine the role of β-lactamase in β-lactam resistant bacteria originating in odontogenic infections. 169 strains of P. intermedia (case A, 52strains, case B, 35strains and case C, 82strains) which were isolated from closed abscesses of endodontic origin were used in this experiment after identification of the microdilution plate hybridization method.In the cases of A and C, the MIC90 of cefaclor was the largest among the drugs used, and their values became smaller in the order latamoxef, ceftizoxime and cefteram.The MIC90s of cefmetazole and imipenem were as small as those of other antibiotics except for Plactams.The MIC90 in case B was lower than that in cases A and C.β-Lactamase activity dffers with the case.Hydrolysis to substrates ampicillin (ABPC) and cefazolin (CEZ) was high in case A, and low in case B.However, in case C the ability of β-lactamase to hydrolyze substrate CEZ was high, but it was low for substrate ABPC.β-Lactamase chiefly hydrolyzed only substrate CEZ or both substrates ABPC and CEZ. Most of the isolates for which a drug had a higher MIC also had high β-lactamase activity, but in some isolates these was no relationship between the MIC and β-lactamase acitivity.These results suggest that β-lactamases which strongly hydrolyzed CEZ are closely related to the mechanism of β-lactam resistance in P.intermedia isolated from odontogenic infections, but we must also study mechanisms of β-lactam resistance other than that of β-lactamase.

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