新鮮分離グラム陽性菌に対するgrepafloxacinの抗菌活性

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  • Antibacterial activity of grepafloxacin against fresh clinically isolates gram-positive bacteria

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To investigate antibacterial spectrum and antibacterial activity of grepafloxacin (GPFX), MICs of GPFX as well as other antibiotics were determined against standard strains of gram-positive and grampositive bacteria clinically isolates obtained in 1993.<BR>The results obtained are summarized as follows:<BR>1. Antibacterial high activity of GPFX was suggested by MICs against gram-positive bacteria. MIC90 of GPFX against methicillin (DMPPC)-resistant Staphylococcus aureus subsp. aureus, and benzylpenicillininsensitive or-resistant Streptococcus pneumoniae was lowest as compared with reference drug. It was studied that MIC of GPFX against ofloxacin-resistant strains of DMPPC-susceptible S. aureus and Corynebacterium spp. were going up, and suggested that fluoroquinolone-resistant gram-positive bacteria could get cross resistance to GPFX.<BR>2. As antibacterial activity of GPFX against gram-positive bacteria was high, suggesting that it was selected antibiotic at first in community-acquired infection.

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