多剤耐性臨床分離株に対するpazufloxacinの抗菌活性

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  • Antimicrobial activity of pazufloxacin against clinically isolated strains resistant to multiple drugs

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To examine the antimicrobial activity of pazufloxacin (PZFX) against clinically isolated strains resistant to multiple drugs, including new quinolones (NQ), the minimum inhibitory concentrations (MICs) were measured, including those of the control drugs.<BR>The results were as follows:<BR>1. The antimicrobial activity of PZFX against methicillin-resistant Staphylococcus aureus and Enterococcus spp. including ciprofloxacin-resistant Enterococcus faecalis was almost the same as those of other new quinolones.<BR>2. The antimicrobial activity of PZFX against nalidixic acid-resistant Enterobacteriaceae (Escherichia coli, Citrobacter freundii, Kiebsiella pneumoniae, Enterobacter spp., Serratia marcescens, and the Proteus group) was stronger than those of tosufloxacin and ciprofloxacin.<BR>3. The MICs of PZFX against ofloxacin-resistant Pseudomonas aeruginosa were distributed in the high concentration range for the same NQs.

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