尿路感染症に対する経口用キノロン薬balofloxacinの臨床効果

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  • Clinical effects of a quinolone drug for oral use, balofloxacin, on urinary tract infection

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A new quinolone antimicrobial drug, balofloxacin (BLFX), was administered to 31 patients with urinary tract infections, and the clinical effects, safety and usefulness were investigated.<BR>The efficacy, by doctors in charge, was excellent in 6 and good in five of 11 patients with uncomplicated urinary tract infection, and the efficacy was excellent in five and moderate in one of the six patients in whom the results were consistent with the Drug Evaluation Criteria proposed by the Japanese Urinary Tract Infection Committee, for an efficacy rate of 100%. The efficacy was rated as excellent in eight, good in three, fair in two, and poor in four of the 17 patients with comlicated urinary tract infection, according to doctor's evaluation. The efficacy was rated as excellent in seven, moderate in two and poor in one of the 10 patients in whom the results were consistent with the Drug Evaluation Criteria proposed by the Japanese Urinary Tract Infection Committee, for an efficacy rate of 90%. The efficacy was excellent in one patient with acute prostatitis and good in one with non-gonococcal and non-chlamydial urethritis.<BR>Bacteriologically, all clinical isolates, consisting of nine strains from simple urinary tract infection, 17 strains from complex urinary tract infection and one strain from acute prostatitis, were eradicated by administration of the drug.<BR>Nausea and gastric discomfort were observed in one patient each and headache and pruritis were observed in one patient, as subjective and objective side effects.<BR>No abnormal changes in clinical laboratory test values were observed.<BR>These results suggest that BLFX, a quinolone drug for oral use, is useful for treating urinary tract infection.

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