耳鼻咽喉科領域感染症に対するNM441の基礎的・臨床的検討

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  • Evaluation of NM441 in treatment of otorhinolaryngological infections

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We evaluated the efficacy and safety of NM441, a new oral quinolone, in the treatment of otorhinolaryngological infections.<BR>Tissue concentrations in mucous membrane of maxillary sinus after 200mg p.o. were 1.47 and 0.19μg/g.<BR>The drug was clinically evaluated in 33 patients with otorhinolaryngological infections. Overall clinical efficacy was excellent in 11, good in 14, fair in 5 and poor in 3 cases. The efficacy rate was 75.8%.<BR>Side effect was not observed in 37 patients, and abnormal laboratory findings were found in 2 cases; slight elevations of GOT · EGPT and total bilirubin.<BR>From these results, NM441 was shown to be highly useful for the treatment of various otorhinolaryngological infections.

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