β‐ｌａｃｔａｍ　ａｎｔｉｂｉｏｔｉｃ‐ｉｎｄｕｃｅｄ　ｖａｎｃｏｍｙｃｉｎ　ｒｅｓｉｓｔａｎｔ　ＭＲＳＡに対する各種抗菌薬の抗菌力

• 前橋 一紀

  明治製菓株式会社感染症研究所

• 田端 麻紀子

  明治製菓株式会社感染症研究所

• 谷 眞理子

  明治製菓株式会社感染症研究所

• 清水 正樹

  明治製菓株式会社感染症研究所

• 加藤 佳久

  明治製菓株式会社感染症研究所

• 疋田 宗生

  明治製菓株式会社感染症研究所

書誌事項

タイトル別名

• In vitro activity of antibacterial agents against .BETA.-lactam antibiotic-induced vancomycin resistant MRSA

抄録

We compared the sensitivity of methicillin-resistant Staphylococcus aureus (MRSA) to drugs such as arbekacin (ASK), vancomycin (VCM) and teicoplanin (TEIC) in β-lactam antibiotic-induced VCM-resistant MRSA (BIVR) and non-BIVR strains. MRSA clinical isolates (121 strains) were classified into 16 strains of BIVR and 105 strains of non-BIVR due to the existence of antagonism between ceftizoxime (CZX) and VCM in an Mu3 medium. There was a slight difference between the susceptibility of BIVR and non-BIVR to ABK. The antibacterial activity of ABK was also not affected in combination with low-concentrations of CZX (0.06 or 1μg/mL). On the other hand, the minimum inhibitory concentrations, MIC₅₀, and MIC₉₀, of VCM against BIVR strains were both twice higher than against non-BIVR strains, and were also 4 times higher thanagainst non-BIVR strains in cornbination with CZX. Although the antibacterial activity of TEIC against BIVR strains did not change in the presence of CZX, the MTC₅₀ and MIC₉₀ of TEIC alone were 8 and 4 times higher thanagainst non-BIVR strains, respectively. Next, the relationship between the MIC of TEIC and detection frequency of BIVR strains was investigated. As a result, the higher the MIC of TEIC, the more frequently BIVR strains were found. Furthermore, BIVR strains were isolated from non-BIVR sub-populations with diminished susceptibility to TEIC.<BR>In conclusion, the antibacterial activity of ABK was not changed by the difference between BIVR and non-BIVR strains. On the other hand, VCM showed antagonistic effects in combination with CZX at low concentrations against BIVR strains. TEIC alone was less effective against BIVR strains, although TEIC did not reveal any antagonistic effect against BIVR strains in combination with CZX.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 53 (1), 5-10, 2005

  公益社団法人 日本化学療法学会

キーワード

• MRSA
• arbekacin
• vancomycin
• teicoplanin
• β-lactarn antibiotic-induced vancomycin resistant MRSA

詳細情報

• CRID: 1390282681263085568
• NII論文ID: 130004298232
• NII論文ID: 10014313094
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.53.5
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2005129567
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可