癌化学療法における口内炎に対するバリダーゼ・キシロカイン含有含嗽剤の臨床効果

DOI NDLデジタルコレクション 被引用文献1件 参考文献11件

書誌事項

タイトル別名
  • Clinical Effects of Gargle Containing Varidase and Xylocaine on Stomatitis induced by Cancer Chemotherapy.
  • 癌化学療法における口内炎に対するバリダーゼ・キシロカイン含有含そう剤の臨床効果

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抄録

At Nagoya University Hospitald to increase the QOL in patients suffering from pain, we prepare a gargle containing Varidase® and Xylocaine® for the treatment of stomatitis during cancer chemotherapy. The gargle contained sodium azulene sulfonate, lidocaine hydrochloride, Varidase (mixture of streptokinase and streptodornase), and hydroxypropylmethyl-cellulose in distilled water. We evaluated the effect of the gargle on stomatitis patients. In this study, we adjusted the concentration of lidocaine (0.12, 0.24, 0.60, and 1.00 mg/mL of water) to control the pain induced by different degrees of stomatitis. We determined the appropriate concentrations of lidocaine in the gargle to be 0.24, 0.60, and 0.60-1.00 mg/mL, for mild, moderate and severe cases of stomatitis, respectively. After the most suitable concentration of lidocaine in the gargle was determined, the treatment was continued. We analyzed the relationship between the total amount of gargle and the effects of treatment on stomatitis. The treatment periods for stomatitis were shortened by increasing the total amount of gargle, in other words, the patients used the gargle at more frequent intervals per day. Based on these findings gargle containing Varidase and Xylocaine is therefore cinsidered be effective for the treatment of stomatitis.

収録刊行物

  • 病院薬学

    病院薬学 25 (5), 525-531, 1999

    一般社団法人 日本医療薬学会

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