薄層クロマトグラフイーによる注射薬の配合変化について

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タイトル別名
  • Thin-Layer Chromatographic Studies on the Change of Medicinals for Injection by Combination
  • ハクソウ クロマトグラフィー ニ ヨル チュウシャヤク ノ ハイゴウ ヘンカ ニ ツイテ

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With the purpose to know the combinations of drugs which produce chemical changes without apparent changes by admixing and to identify the substances there produced, thin-layer chromatography has been applied to the experiments with different combinations of reduced-form glutathione and various drugs for injection for detection of the changes due to the admixture.<br>Thin-layer plates are prepared with Wakogel B-5 (25μ thick, 200mm×50mm), Sample drugs are admixed in identical volume, and after leaving for 10 minutes, equimolar to twice molar N-ethylmaleimide is dissolved in the mixed solution, and the whole is spotted at the middle of the starting line while the component solutions are spotted on both side before development is carried out to the extent of 10cm of distance.<br>The experimental results are summarized as follows.<br>(1) Combinations that gave no visual changes as well as no changes in thin-layer chromatograms showing symmetrical spots are: Sigmamycin, Ilotycin, Viccillin, Hostacyclin, Leucomycin, Dicinone, Coagumin, Transamin, Adona, Trostin, Vitamin B1, Vitamin B2, Flavitan, Vitamin B6, Fresmin, Vitamin C, Vitamin K1, Vitamin K3, Pancal, Guronsan, Methionin, Inosie, Sohamin G, Glucose, Fructose, Klinit, Pyretia, Dehycol and Trinosin S.<br>(2) Combinations that gave no visual changes but produced anomalous spots on thin layer chromatograms are: Alinamin F and Neuvita.<br>Due to the action of the SH group in glutathione vitamin B1 in these drugs should have been liberated to produce a mercaptan odor, resulting in fall of the residual rate. These combinations are recommended to avoid.<br>(3) Combination that gave visual changes but no changes on thin-layer chromatogram is: Terramycin.<br>(4) On Tetracyclin, Pyretia and Pancal, reports have been published recommending prohibition of the combination, but in the present studies no changes have been observed in appearance and on thin-layer chromatogram. With Pancal, residue rate was determined after different time of leaving to find no anomalous phenomenon in particular.

収録刊行物

  • 医療

    医療 22 (7), 846-852, 1968

    一般社団法人 国立医療学会

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