血圧の季節的変動における降圧剤の効果について

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  • Effects of antihypertensive drugs on seasonal variation in blood pressure.

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Aspects of seasonal variation in blood pressure and influences of antihypertensive treatment on them were studied by use of design of experiments. Two year follow-up studies were carried out on 30 patients with essential hypertension under the treatment with Indenolol hydrochloride as β-blocker, Nicardipine hydrochloride as Ca-antagonist, Trichloromethiazide as diuretics, respectively. Systolic and diastolic arterial blood pressures were measured by sphygmomanometry. Left ventricular ejection fraction, stroke volume and heart rate were measured by echocardiogram and Doppler cardiogram. These numbers were set into the 2×3 square columns, and the mean square of unbiased estimation of population variance between columns as well as between rows were calculated and significance of interaction was tested. The seasonal variation of blood pressure was recognized to be deformed by the antihypertensive drugs. The way of being deformed was different among the three according to their pharmacological properties.

収録刊行物

  • 医療

    医療 41 (8), 702-706, 1987

    一般社団法人 国立医療学会

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