肝細胞癌における癌遺伝子産物ｐｐ６０｀ｃ－ｓｒｃ´の活性増強　癌部と非癌部の比較検討

• 正木 勉

  国立療養所高松病院内科 香川医科大学第3内科学

• 徳田 雅明

  香川医科大学生理学

• 谷口 清英

  国立療養所高松病院外科

• 藤井 正吾

  国立療養所高松病院内科

• 岡本 佐智子

  国立療養所高松病院看護部

• 畑中 良夫

  国立療養所高松病院内科

• 畠瀬 修

  香川医科大学生理学

• 西岡 幹夫

  香川医科大学第3内科学

書誌事項

タイトル別名

• Protooncogene Product, pp60c-src Activation in Hepatocellular Carcinoma. A Comparative Study in Tumorous and Adjacent Nontumorous Portions of Hepatocellular Carcinoma.
• A COMPARATIVE STUDY IN TUMOROUS AND ADJACENT NONTUMOROUS PORTIONS OF HEPATOCELLULAR CARCINOMA
• ―癌部と非癌部の比較検討

抄録

Nine src family members are known to date: c-src, c-yes, c-lck, c-fyn, c-hck, c-lyn, c-blk, c-fgr and c-yrk. They encode proteins of molecular weights of 55 to 62 kilodaltons, which are non-receptor type, membrane associated and protein tyrosine kinases. For the related Src kinases, a close correlation exists between elevated tyrosine kinase activity and cell transformation. However, the involvement of pp 60^c-src in human hepatocellular carcinoma remains obscure. In this study, we analyzed the amount of pp 60^c-src at protein and/or kinase activity levels in tumorous and adjacent nontumorous portions of hepatocellular carcinoma from the same patient. The kinase activity of pp 60^c-src was significantly elevated in the tumorous tissue, than in the nonmtumorous cirrhotic portions. These results suggest that activation of the protooncogene product pp 60^c-src may play an important role in the malignant transformation of hepatocytes in human liver.

収録刊行物

• 医療

  医療 50 (11), 759-762, 1996

  一般社団法人 国立医療学会

キーワード

• 肝細胞癌

詳細情報

• CRID: 1390282681292118528
• NII論文ID: 130004315344
• DOI: 10.11261/iryo1946.50.759
• ISSN: 18848729
• ISSN: 00211699
• Web Site: https://search.jamas.or.jp/link/ui/1997108066
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可