亜急性硬化症全脳炎（ＳＳＰＥ）の臨床

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タイトル別名
  • Subacute Sclerosing Panencephalitis(SSPE).
  • アキュウセイ コウカショウ ゼン ノウエン(SSPE)ノ リンショウ

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抄録

Subacute sclerosing panencephalitis (SSPE) is a typical disease of slow virus infection caused by measles virus. It develops after the incubation period of several years and is most frequent following infection in the first two years of life. Measles virus involves to central nervous system but not involves to the other organs. Its prognosis is bad. The incidence of this disease is said to be 1 per 1, 000, 000 and SSPE seems to occur only exceptionally following attenuated vaccinal measles. No general immunological deficiency is present but response to measles infection may be abnormal. The absence of synthesis of the M viral protein is recognized in infected brain cell of SSPE.<br>The diagnosis is performed from the clinical course and laboratory findings such as the rise of the measles antibody titer in serum and cerebrospinal fluid (CSF), the rise of Ig-G in CSF and electroencephalogram.<br>Though no satisfactory treatment has been developed, it is thought that the combind treatment of inosinpranobex and interferon is effective. Several patients of SSPE per year are still developed now in Japan. The spread of measles vaccine is important to prevent the developing of SSPE.

収録刊行物

  • 医療

    医療 56 (2), 73-79, 2002

    一般社団法人 国立医療学会

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