自然発症肝炎・肝癌ラット（ＬＥＣラット）における着色歯の検索　第１報　病理組織学的検討

DOI

書誌事項

タイトル別名
  • Analysis of Pigmented Teeth in LEC(Long Evans Cinnamon) Rat with Spontaneous Hepatitis and Hepatoma. Part 1. Histopathological Analysis.
  • Part 1: Histopathological Analysis
  • 第1報: 病理組織学的検討

この論文をさがす

抄録

It is known that LEC (Long Evans Cinnamon) rat has been separated from Long Evans rat closed colony and spontaneously developed acute hepatitis accompanied with severe jaundice about 4 months after birth, and that the clinical signs of hepatitis resemble human fulminant hepatitis. We noticed that the green-pigmented incisors in LEC rat erupted 3 weeks after hereditary acute hepatitis. In this paper, we studied the pigmented incisors histopathologically using an optical microscope, microradiography, and scanning electron microscope. The green pigmentation was observed as a green stripe in the dentin and the stripe ran parallel to the incremental line. In the pigmentation area, we also noticed the interglobular like structure and abnormal dentinal tube. The microradiographic analysis disclosed enhanced permeability of the pigmented area as compared with other areas. Furthermore, considering the course of teeth eruption in the rat's incisors, this pigmented area was formed during acute hepatitis and jaundice. These results suggested that acute hepatitis and jaundice in LEC rat caused green-pigmented incisors and hypocalcification and hypoplasia of the matrix in the dentin, and we suspected that pigmentation was caused by bilirubin. LEC rat thus seems to be a very useful animal as a model for analysis of the teeth pigmentation following hepatitis and jaundice in humans.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ