｀９９ｍ´Ｔｃ‐ＭＤＰの骨組織への集積機序　第２報　ハイドロキシアパタイトおよびカルシウム化合物に対する｀９９ｍ´Ｔｃ‐ＭＤＰの吸着とその吸着に影響する因子

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  • Accumulation Mechanisms of 99mTc-MDP in Bone. Part II. 99mTc-MDP Adsorption in Hydroxyapatite and Calcium Compounds, and Factors Affecting on the Adsorption.
  • Part II: <SUP>99m</SUP>Tc-MDP Adsorption in Hydroxyapatite and Calcium Compounds, and Factors Affecting on the Adsorption
  • 第2報 ハイドロキシアパタイトおよびカルシウム化合物に対する<SUP>99m</SUP>Tc-MDPの吸着とその吸着に影響する因子

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The accumulation mechanisms of 99mTc-MDP (technetium-99m methylene diphosphonate) were investigated using hydroxyapatite powder and calcium compounds. After incubation with 99mTc-MDP, radioactivity was analyzed using a scintillation counter. Adsorption of 99mTc-MDP in hydroxyapatite powder was pH-dependent, with the adsorption being the lowest in the neutral range, and the highest at pH 5.5. Physiological concentration of Na+ and K+ slightly inhibited the adsorption in hydroxyapatite powder, however, the Ca2+ and Mg2+ had no effect on 99mTc-MDP adsorption. ATP and GTP inhibited the absorption in a dose dependent manner. Among the six tested calcium compounds types, only calcium pyrophosphate demonstrated adsorption of 99mTc-MDP.<BR>The results indicate that the crystalline structure of hydroxyapatite may be important for 99mTc-MDP accumulation in bone. Additionally, pH-changes in tissue may increase the adsoration of 99mTc-MDP in bone.

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