Glybuzoleの膵α細胞機能に及ぼす影響に関する実験的および臨床的研究

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タイトル別名
  • Experimental and Clinical Studies on the Effect of Glybuzole upon the Alpha Cell Function of the Pancreas
  • Glybuzole ノ スイ アルファ サイボウ キノウ ニ オヨボス エイキ

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To determine the direct effect of glybuzole upon the secretion of pancreatic glucagon, 100mg of glybuzole was infused for 10 minutes into the pancreatic artery of six anesthetized dogs.Blood glucose in the femoral artery decreased gradually 15 minutes and later following glybuzole infusion. Plasma insulin in the pancreatic vein rcse from a base line of 164.0±30.6 to a peak of 352.3±99.3μU/m/ at 3 minutes (p<.05). Plasma glucagon in the pancreatic vein de;reased promptly from a base line of 1.34±0.12 mpg/m/ and reached the nadir of 0.92±0.18 mpg/m/ at 6 minutes (p<.05). The glucagon level, however, returned gradually to the initial level after the withdrawal of the glybuzole infusion. To compare the effect of glybuzole with the other sulfonylurea drugs, glybuzole, tolbutamide and glibenclamide were infused successively for ten minutes into the pancreatic artery at 40-minute intervals in a group of three dogs. 100 mg of glybuzole induced a more marked decrease in the plasma level of glucagon compared with 200mg of tolbutamide or lmg of glibenclamide.<BR>Pancreatic glucagon response to arginine infusion was investigated before and after the treatment with glybuzole in 5 diabetic patients. Approximately one month after glybuzole administration, blood glucose levels, either fasting or after arginine infusion, were significantly lower than those before the treatment. Plasma glucagon levels during arginine infusion tests were lower after the glybuzole treatment compared with those before the treatment. Significant changes in the plasma glucagon were observed before and 5 and 20 minutes after the start of the arginine infusion.<BR>These results showed the direct effect as well as the chronic effect of glybuzole upon the alpha cell function of the pancreas.

収録刊行物

  • 糖尿病

    糖尿病 18 (2), 149-155, 1975

    一般社団法人 日本糖尿病学会

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