ストレプトゾトシン糖尿病ラットにおけるβ‐エンドルフィン様免疫活性の分泌動態に関する研究

• 溝渕 猛

  徳島大学医学部第二内科

• 松村 光博

  徳島大学医学部第二内科

書誌事項

タイトル別名

• The release of .BETA.-endorphin-like immunoreactivity in rats with streptozotocin-induced diabetes.

抄録

To study the release of β-endorphin-like immunoreactivity (β-EpLI) in diabetes mellitus, two groups of diabetic rats were prepared by administration of 30 or 60mg/kg body weight of streptozotocin (STZ). Concentrations of insulin and β-EpLI in portal plasma and various tissues were measured in these rats, and the following results were obtained.<BR>1. Concentrations of β-EpLI in portal plasma and pancreatic tissues of both groups of STZ-induced diabetic rats were significantly increased as compared with those of the control group.<BR>2. Concentrations of β-EpLI in the pituitary tissues of both groups of STZ-induced diabetic rats did not change significantly as compared with those of the control group.<BR>3. Portal plasma levels of β-EpLI and the concentration of β-EpLI in the pancreatic tissue of diabetic rats (60mg/kg body weight) given lente insulin every day differed little from those of the control group.<BR>These results suggested that the pancreas might participate, at least partly, in the increase of β-EpLI release in STZ-induced diabetic rats. Furthermore, from the observations that portal plasma levels of β-EpLI in STZ-induced diabetic rats given lente insulin for seven days were similar with those of the control group, it was considered that increases of portal plasma β-EpLI in rats with STZ-induced diabetes were due to insulin deficiency.

収録刊行物

• 糖尿病

  糖尿病 31 (9), 739-744, 1988

  一般社団法人 日本糖尿病学会

キーワード

• β-エンドルフィン様免疫活性
• ストレプトゾトシン糖尿病ラット
• 膵ホルモン
• インスリン処置

詳細情報

• CRID: 1390282679883179264
• NII論文ID: 130004337647
• DOI: 10.11213/tonyobyo1958.31.739
• ISSN: 1881588X
• ISSN: 0021437X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可