糖尿病を合併した４８，ＸＸＹＹ　Ｋｌｉｎｅｆｅｌｔｅｒ症候群の１例

• 渋谷 雄平

  西神戸医療センター内分泌糖尿内科

書誌事項

タイトル別名

• A Case of 48, XXYY Klinefelter's Syndrome Associated with Diabetes Mellitus.

抄録

A patient with 48, XXYY Klinefelter's syndrome accompanied by diabetes mellitus is reported. A 34-year-old man with diabetes diagnosed at the age of 26 years had been treated with insulin (44 U/day). He was referred to our hospital because of thirst, polyuria, general malaise, and poor glycemic control (HbA_1c 13.6%). On examination he was found to have mental retardation, radioulnar synostosis, varicose veins, gynecomastia, and small testes. Endocrinologically the serum testosterone level was low and basal LH and FSH levels were elevated. Urinary C-peptide (CPR) was 10.5-14.4 μg/day and serum CPR showed a low response to glucagon. Anti-islet cell antibody and anti-GAD antibody were both negative. Chromosomal analysis showed that the cell karyotype was 48, XXYY, and the patient was diagnosed as having a rare variant of Klinefelter's syndrome.

収録刊行物

• 糖尿病

  糖尿病 40 (9), 619-623, 1997

  一般社団法人 日本糖尿病学会

キーワード

• 糖尿病
• Klinefelter症候群
• 48, XXYY症候群

詳細情報

• CRID: 1390001204905964800
• NII論文ID: 130004338399
• DOI: 10.11213/tonyobyo1958.40.619
• ISSN: 1881588X
• ISSN: 0021437X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可