2型糖尿病患者におけるラクナ梗塞危険因子としての血中PAI‐1濃度測定の意義

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タイトル別名
  • Clinical Significance of PAI-1 for Lacunar Infarction in Type 2 Diabetic Patients.
  • 2ガタ トウニョウビョウ カンジャ ニ オケル ラクナ コウソク キケン インシ ト シテ ノ ケッチュウ PAI-1 ノウド ソクテイ ノ イギ

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抄録

We studied whether plasminogen activator inhibitor 1 (PAI-1) was a risk factor for lacunar infarction in type 2 diabetic patients. Although PAI-1 was not related to HbA1c concentrations and advanced glycation endproducts (AGEs) or fasting CPR, it was related significantly to the percent of body fat (%BF), body mass index (BMI) and average blood pressure. PAI-1 was also related to platelet count, fibrinogen level and the number of lacunar infarctions analyzed with brain magnetic resonance imaging (MRI). These results suggest that PAI-1 may be a risk factor for lacunar infarction by activating coagulation and inhibiting fibrinolysis in cerebrovascular lesions in type 2 diabetic patients.

収録刊行物

  • 糖尿病

    糖尿病 45 (8), 577-582, 2002

    一般社団法人 日本糖尿病学会

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