一過性甲状腺機能こう進症を伴った重症妊娠悪阻と妊娠中毒症を合併したＭＯＤＹの１例

• 萬代 幸子

  九州大学大学院病態機能内科学

• 岩瀬 正典

  九州大学大学院病態機能内科学

• 向井 直子

  九州大学大学院病態機能内科学

• 中村 宇大

  九州大学大学院病態機能内科学

• 市川 晃治郎

  九州大学大学院病態機能内科学

• 飯田 三雄

  九州大学大学院病態機能内科学

書誌事項

タイトル別名

• A Case of Hyperemesis Gravidarum and Preeclampsia in MODY Associated with Transient Hyperthyroidism

抄録

A 33 year old woman admitted for frequent vomiting when 10 weeks pregnant. She had developed diabetes mellitus at age 15 and was diagnosed as MODY. Pregnancy was detected under well-controlled conditions of 6.8% of HbA_1c and normoalbuminuria. Hyperemesis gravidarum was diagnosed and parental hyperalimentation implemented. Although she had no thyrotoxic symptoms or struma, hyperthyrodism was detected (free T4 1.9ng/dl, free T3 4.5pg/ml, TSH<0.03μU/ml). Since antithyroid or TSH receptor antibodies were negative and serum chorionic gonadotropin (hCG) was 147, 600mU/ml, hyperthyroidism due to elevated serum hCG was diagnosed. Her symptoms and hyperthyroidism were ameliorated along with the lowering of serum hCG until 18 weeks of gestation. In the second term, however, she developed toxemia of pregnancy and was readmitted at 31 weeks of gestation. At 36 weeks of gestation, a normal fetus was delivered by Caesarean section. After delivery, diabetic retinopathy and hypertension were transiently aggravated and urinary albumin excretion did not normalize until one year after delivery. hCG may thus induce transient hyperthyroidism and hyperemesis gravidarum due to its thyroid stimulating activity and may be related to the development of preeclampsia.

収録刊行物

• 糖尿病

  糖尿病 46 (6), 447-453, 2003

  一般社団法人 日本糖尿病学会

キーワード

• 妊娠悪阻
• 妊娠中毒症
• ヒト絨毛性ゴナドトロピン
• MODY

詳細情報

• CRID: 1390001204904015232
• NII論文ID: 130004338923
• DOI: 10.11213/tonyobyo1958.46.447
• ISSN: 1881588X
• ISSN: 0021437X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可