易感染性が著明であった自己免疫性好中球減少症の1乳児例 ST合剤の隔日投与による感染予防
書誌事項
- タイトル別名
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- An infant case of autoimmune neutropenia.
- ST合剤の隔日投与による感染予防
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A nontransfused 10-month-old female infant was admitted for recurrent infections and fever. On admission, absolute neutrophil counts ranged from 112 to 998/μl. Antibodies against neutrophils were examined with an indirect immunofluorescence test (GIIFT) and a microleukocyte agglutination test (MLAT). The patient's sera reacted with neutrophils from normal donors on GIIFT and MLAT. The results of a leukocyte cytotoxicity test were negative. These findings suggest that her neutropenia was caused by the autoantibody against neutrophils. Trimethoprim-sulfamethoxazole was given orally at a dose of 6 mg (trimethoprim) /kg/day every other day. Although the neutrophil counts did not increase after the treatment, the frequency of infections remarkably decreased. We conclude that oral administration of trimethoprim-sulfamethoxazole every other day was effective for the prophylaxis of infections of in our patient with autoimmune neutropenia.
収録刊行物
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- 日本小児血液学会雑誌
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日本小児血液学会雑誌 4 (5), 470-474, 1990
特定非営利活動法人 日本小児血液・がん学会
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詳細情報 詳細情報について
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- CRID
- 1390001204342381312
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- NII論文ID
- 130004346074
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- ISSN
- 18844723
- 09138706
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可