HRP (Horseradish Peroxidase) 感作モルモットの内耳免疫反応

• 石田 孝

  弘前大学医学部耳鼻咽喉科教室

• 朴沢 二郎

  弘前大学医学部耳鼻咽喉科教室

• 鎌田 重輝

  弘前大学医学部耳鼻咽喉科教室

• 木村 訓子

  弘前大学医学部耳鼻咽喉科教室

• 宇佐美 真一

  弘前大学医学部耳鼻咽喉科教室

• 上村 敏夫

  弘前大学医学部耳鼻咽喉科教室

書誌事項

タイトル別名

• Immunological Labyrinthine Reactions of Guiea-pigs Sensitized by Horseradish Peroxidase

抄録

The labyrinths of guinea-pigs sensitized by horseradish peroxidase (HRP) were investigated by electronmicroscopy after challenging this antigen through the foram. stylomastoideum. Horizontsl nystagmus toward the contralateral side was observed about fifteen minutes after challenging. The animals sacrified in this stage did not show endolymphatic hydrops, however, particles of HRP were observed in intracellular vesicles and basal lamina of Reissner's membrane. This particles were took in dark cells of the stria vascularis, too. In the animals sacrified three days after challenging HRP, endolymphatic hydrops could be observed. These findings were not observed in the control study and suggested that hyperpermeability of the Reissner's membrane and hypersecretion of the stria vascularis induced by antigen-antibodyreactions were probable causes of endolymphatic hydrops.

収録刊行物

• Ｅａｒ　Ｒｅｓｅａｒｃｈ　Ｊａｐａｎ

  Ｅａｒ　Ｒｅｓｅａｒｃｈ　Ｊａｐａｎ 13 (1), 145-147, 1982

  日本耳科学会

詳細情報

• CRID: 1390001204771091712
• NII論文ID: 130004355002
• DOI: 10.11289/otoljpn1981.13.145
• ISSN: 18845797
• ISSN: 02889781
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可