スギ花粉症における予防的投薬の検討:(I) DSCG, Tranilastの予防効果 A New Treatment of Japanese Cedar Pollinosis:Prophylactic efficacy of Tranilast and DSCG
We evaluated the prophylactic efficacy of Tranilast and DSCG for patients with Japanese Cedar pollinosis. Each medication was taken four-times or twice daily throughout the pollen season from preseasonal period. The effective rates were 65% in Tranilast group, 44% in DSCG group. In this trial, Tranilast was more effective than DSCG. In the Tranilast group, the nasal symptom was improved, and the effective rate was as high as 70% in sneezing attacks, 59% in rhinorrhea and 59% in nasal obstruction. Tranilast inhibited the nasal provocation test, but gave no significant change of total IgE, IgE antibody and blood eosinophils. The prophylactic method of Tranilast administration was considered to be an available therapy for patients with Japanese Cedar pollinosis.
耳鼻と臨床 32(3), 416-424, 1986