耳鼻咽喉科領域感染症におけるFlomoxef (6315-S) の基礎的,臨床的検討

• 馬場 駿吉

  Department of Otorhinolaryngology, School of Medicine, Nagoya City University, Nagoya 467, Japan

• 稲垣 光昭

  Department of Otorhinolaryngology, School of Medicine, Nagoya City University, Nagoya 467, Japan

• 海野 徳二

  Department of Otorhinolaryngology, Asahikawa Medical University, Asahikawa 078, Japan

• 上戸 敏彦

  Department of Otorhinolaryngology, Asahikawa Medical University, Asahikawa 078, Japan

• 柳内 統

  Department of Otorhinolaryngology, Asahikawa Red Cross Hospital

• 野中 聡

  Department of Otorhinolaryngology, Wakkanai Municipal Hospital

• 市川 良之

  Department of Otorhinolaryngology, Wakkanai Municipal Hospital

• 古内 一郎

  Department of Otorhinolaryngology, Dokkyo Medical University

• 河村 正三

  Department of Otorhinolaryngology, School of Medicine, juntendo University

• 芳川 洋

  Department of Otorhinolaryngology, School of Medicine, juntendo University

• 桜井 淳

  Department of Otorhinolaryngology, School of Medicine, juntendo University

• 板橋 隆嗣

  Department of Otorhinolaryngology, Koto Hospital

• 和田 昌士

  Department of Otorhinolaryngology, Tokyo Rosai Hospital

• 藤巻 豊

  Department of Otorhinolaryngology, Katsunan Hospital

• 渡辺 洋

  Department of Otorhinolaryngology, Taketani Hospital

• 野村 恭也

  Department of Otorhinolaryngology, School of Medicine, Tokyo University

• 仙波 哲雄

  Department of Otorhinolaryngology, School of Medicine, Tokyo University

• 鳥山 寧二

  Department of Otorhinolaryngology, Musashino Red Cross Hospital

• 渡辺 博紀

  Department of Otorhinolaryngology, Kameda General Hospital

• 市村 恵一

  Department of Otorhinolaryngology, Tokyo Metropolitan Fuchu Hospital

• 庄司 稔

  Department of Otorhinolaryngology, Takeda General Hospital

• 三宅 浩郷

  Department of Otorhinolaryngology, School of Medicine, Tokai University

• 新川 敦

  Department of Otorhinolaryngology, School of Medicine, Tokai University

• 坂本 裕

  Department of Otorhinolaryngology, Kawasaki City Hospital

• 大西 信治郎

  Department of Otorhinolaryngology, Kanto Teisin Hospital

• 西村 忠郎

  Department of Otorhinolaryngology, Fujitagakuen Hoken Eisei University Second Hospital

• 鈴木 昭男

  Department of Otorhinolaryngology, Fujitagakuen Hoken Eisei University Second Hospital

• 丸尾 猛

  Department of Otorhinolaryngology, Koseiren Showa Hospital

• 伊藤 晴夫

  Department of Otorhinolaryngology, Koseiren Showa Hospital

• 松永 亨

  Department of Otorhinolaryngology, School of Medicine, Osaka University

• 浅井 英世

  Department of Otorhinolaryngology, School of Medicine, Osaka University

• 玉置 弘光

  Department of Otorhinolaryngology, Osaka Prefectural Hospital

• 金 聖真

  Department of Otorhinolaryngology, Osaka Prefectural Hospital

• 石田 稔

  Department of Otorhinolaryngology, Suita City Hospital

• 田矢 直三

  Department of Otorhinolaryngology, Suita City Hospital

• 松永 喬

  Department of Otorhinolaryngology, NaraMedical University

• 岩崎 壽美

  Department of Otorhinolaryngology, NaraMedical University

• 柏木 令子

  Department of Otorhinolaryngology, NaraMedical University

• 梁川 明久

  Department of Otorhinolaryngology, Nara Prefaectural Nara Hospital

• 北奥 恵之

  Department of Otorhinolaryngology, Nara Prefaectural Nara Hospital

• 折田 洋造

  Department of Otorhinolaryngology, Kawasaki Medical School

• 秋定 健

  Department of Otorhinolaryngology, Kawasaki Medical School

• 涌谷 忠雄

  Department of Otorhinolaryngology, Shimane Medical University

• 藤野 有弘

  Department of Otorhinolaryngology, Shimane Medical University

• 寺嶋 正治

  Department of Otorhinolaryngology, Shimane Medical University

• 尾中 良久

  Department of Otorhinolaryngology, Tokuyama Central Hospital

• 関谷 透

  Department of Otorhinolaryngology, School of Medicine, Yamaguchi University

• 沖中 芳彦

  Department of Otorhinolaryngology, School of Medicine, Yamaguchi University

• 平田 哲康

  Department of Otorhinolaryngology, School of Medicine, Yamaguchi University

• 日吉 正明

  Department of Otorhinolaryngology, School of Medicine, Yamaguchi University

• 齋藤 春雄

  Department of Otolaryngology, Kochi Medical School

• 木村 正

  Department of Otolaryngology, Kochi Medical School

• 茂木 五郎

  Department of Otorhinolaryngology, Oita Medical University

• 黒野 祐一

  Department of Otorhinolaryngology, Oita Medical University

• 佐藤 春生

  Department of Otorhinolaryngology, Oita Medical University

• 弓崎 明輝

  Department of Otorhinolaryngology, Oita Prefectural Hospital

• 吉村 弘之

  Department of Otorhinolaryngology, Oita Prefectural Hospital

• 進 武幹

  Department of Otorhinolaryngology, Saga Medical University

• 渡部 俊

  Department of Otorhinolaryngology, Saga Medical University

• 古川 満

  Department of Otorhinolaryngology, Saga Prefaectural Hospital

• 森満 保

  Department of Otorhinolaryngology, Miyazaki Medical University

• 林 明俊

  Department of Otorhinolaryngology, Miyazaki Medical University

• 笠野 藤彦

  Department of Otorhinolaryngology, Miyazaki Medical University

• 牧野 浩二

  Department of Otorhinolaryngology, Miyazaki Medical University

• 柊山 幹子

  Department of Otorhinolaryngology, Miyazaki Medical University

• 永井 みどり

  Department of Otorhinolaryngology, Miyazaki Medical University

• 松元 一郎

  Department of Otorhinolaryngology, Miyazaki Prefectural Hospital

• 東野 哲也

  Department of Otorhinolaryngology, Miyazaki Prefectural Hospital

• 大山 勝

  Department of Otorhinolaryngology, School of Medicine, Kagoshima University

• 古田 茂

  Department of Otorhinolaryngology, School of Medicine, Kagoshima University

• 矢野 博美

  Department of Otorhinolaryngology, School of Medicine, Kagoshima University

• 深水 浩三

  Department of Otorhinolaryngology, School of Medicine, Kagoshima University

• 伊東 一則

  Department of Otorhinolaryngology, School of Medicine, Kagoshima University

• 大野 聖

  Department of Otorhinolaryngology, Minamikyushu National Hospital

• 大野 郁夫

  Department of Otorhinolaryngology, Kagoshima Prefaectural Ohshima Hospital

• 出口 浩一

  Department of Laboratory, Tokyo Clinical Research

書誌事項

タイトル別名

• Fundamental and clinical studies on Flomoxef (FMOX) in otolaryngological infections

抄録

Fundamental and clinical evaluations of the safety and effectivity of FMOX in treating diseases caused by bacterial infections concerning the otorhinolaryngological field were done, and the following results were obtained. 1. FMOX was effective against S. aureus, S. pyogenes, Klebsiella sp., H. influenzae, B. catarrhalis, Anaerobic streptococci and Peptostreptococcus sp. isolated from patients with Various types of otorhinolaryngological infections, most notably, suppurative otitis media. The following data correspond to the MIC of FMOX for each of the above bacteria:≤6.25μg/ml, ≤0.78μg/ml, ≤0.39μg/ml, ≤0.78μg/ml, ≤0.78μg/ml, ≤1.56μg/ ml and≤0.78μg/ml, respectiVely. For S. aureus, FMOX had a far greater antibacterial effect than CTM or LMOX. 2. The maximum concentration in tissue (C_max) of 1g FMOX administered intravenously, was 25.6μg/g in the middle ear and 11.1μg/ml in the tonsils. 3. The percent efficiency of FMOX was measured against a standardized evaluation. FMOX was 56.9% effective against otitis media, 93.4% effective against tonsillitis, 100% effective against pharyngitis and laryngitis, and 75.2% effective against all infections. Physicians evaluated FMOX to have an efficacy of 79.7% against all infections. 4. The rate of bacterial disappearance was high: in infections of Gram-positive bacteria alone, 89.8%, and 75.0% in infections of Gram-negative bacteria alone. FMOX was also rated high at dealing with complex bacterial infections, including those with S. aureus. 5. The percent utility of FMOX was 62.1% against otitis media, 96.7% against tonsillitis, 64.7% against other infections, and 76.5% against all infections. 6. Mild side effects were noted in 5 patients (2.8%: gastrointestinal symptoms and hypersensitivity of the skin). Laboratory examinations uncovered abnormal findings primarily suggesting mild hepatic and renal dysfunction in 7 patients (6.2%), but these Were all temporary. From these results, FMOX is considered to be highly useful for the treatment of otorhinolaryngological infections, most notably suppurative otitis media.

収録刊行物

• 耳鼻と臨床

  耳鼻と臨床 35 (2Supplement1), 394-409, 1989

  JIBI TO RINSHO KAI

キーワード

• 耳鼻咽喉科感染症

詳細情報

• CRID: 1390001205498401024
• NII論文ID: 130004403509
• DOI: 10.11334/jibi1954.35.2supplement1_394
• ISSN: 04477227
• Web Site: https://search.jamas.or.jp/link/ui/1990036058
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可