Modified OligoDNA Having Two Consecutive Silylated-pyrene Moieties in Minor Groove Exhibiting an Excimer Fluorescent Signal upon Binding to Fully Complementary DNA Strand

DOI PDF 被引用文献2件 参考文献12件
  • Mika Mogi
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
  • Md Gias Uddin
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
  • Mayumi Ichimura
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
  • Tomohisa Moriguchi
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
  • Kazuo Shinozuka
    Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University

抄録

<jats:title>Abstract</jats:title> <jats:p>OligoDNA possessing consecutive modified nucleotide residues bearing silylated pyrene at C-2′ position was synthesized. The fluorescent oligoDNA exhibited marked excimer fluorescent signal upon binding to a fully matched complementary DNA strand, however, the signal was effectively quenched in the single-stranded form as well as in the mismatched base pair duplex.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 39 (12), 1254-1255, 2010-10-30

    Oxford University Press (OUP)

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