Tumor Necrosis Factor-α Predicts Response to Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure
-
- Rordorf Roberto
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Savastano Simone
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Sanzo Antonio
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Spazzolini Carla
- Department of Molecular Medicine, Cardiology Section, University of Pavia IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin
-
- De Amici Mara
- Department of Pediatrics, IRCCS Fondazione Policlinico S. Matteo
-
- Camporotondo Rita
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Ghio Stefano
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Vicentini Alessandro
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Petracci Barbara
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- De Regibus Valentina
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Taravelli Erika
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Landolina Maurizio
- Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo
-
- Schwartz Peter J.
- IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin
この論文をさがす
抄録
Background:Pro-inflammatory cytokines contribute to the pathophysiology of heart failure (HF) and are up-regulated in affected patients. We investigated whether pro-inflammatory cytokines might predict the response to cardiac resynchronization therapy (CRT).Methods and Results:Plasma levels of tumor necrosis factor-α (TNF-α) and interleukin-6 were assessed in 91 patients before CRT. Response to CRT was defined as a decrease ≥15% in left ventricular end-systolic volume (LVESV) at 6 months. Baseline TNF-α did correlate with LVESV reduction (P=0.001) after CRT. The subject group was divided according to tertiles of TNF-α. From the lower to the upper tertile LVESV (–31±28%, –17±17%, –9±22%) and LV end-diastolic volume (–23±25%, –14±16%, –4±18%) were progressively less reduced after CRT (P<0.001). The proportion of responders to CRT was 70%, 42% and 33%, according to the lower, intermediate and upper tertile of TNF-α distribution (P=0.01). Serious cardiac events (cardiac death, HF hospitalization or urgent heart transplantation) occurred in 63% of patients in the upper tertile vs. 32% and 17% in the intermediate and lower tertiles, respectively, during a median follow-up of 47 months (P<0.001).Conclusions:Circulating TNF-α predicts the degree of LV reverse remodeling after CRT and may contribute to the early identification of those patients at higher risk of events after device implantation. (Circ J 2014; 78: 2232–2239)
収録刊行物
-
- Circulation Journal
-
Circulation Journal 78 (9), 2232-2239, 2014
一般社団法人 日本循環器学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282680084155904
-
- NII論文ID
- 130004427951
-
- NII書誌ID
- AA11591968
-
- COI
- 1:STN:280:DC%2BC2cfkslOgtA%3D%3D
-
- ISSN
- 13474820
- 13469843
-
- NDL書誌ID
- 025704323
-
- PubMed
- 24954238
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可