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- OHYA Takushi
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- KONDO Takashi
- Epizootic Research Center, Equine Research Institute, Japan Racing Association
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- YOSHIKAWA Yasunaga
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- WATANABE Kiyotaka
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- ORINO Koichi
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
この論文をさがす
抄録
In mammal circulation, various ferritin-binding proteins (FBPs) are thought to be involved in the clearance of circulating ferritin after complex formation with it. However, horse FBPs are known to cause inhibitory effects on ferritin immunoassay due to the concealment of the ferritin molecule to anti-ferritin antibodies used in the ferritin immunoassay. These inhibitory effects are eliminated by heat treatment of horse serum at 75oC for 15 min. The inhibitory effects on ferritin immunoassay in the sera of ten foal sera (5 females and 5 males) from 1 to 18 months were detected during all periods, and ferritin concentrations of the foal sera increased 20-100% as compared with those of untreated sera by same heat treatment. Ferritin concentrations of heat-treated foal sera increased after birth, reaching to ferritin levels of adult horse at 9 months of age. Thereafter, although serum ferritin concentrations fell down at 12 months of age, these concentrations increased to adult levels at 15 months of age again. The ratio of ferritin concentration of heat-treated serum to that of the untreated serum was regarded as an apparent ferritin-binding activity. Ferritin-binding activities in the sera of foals showed peak at 2 and 4 months of age in females and males, respectively. These results suggested that horse FBPs were heat unstable, and FBPs may play an important role in iron metabolism at early developmental stage.<br>
収録刊行物
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- Journal of Equine Science
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Journal of Equine Science 22 (4), 73-76, 2011
日本ウマ科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204369562752
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- NII論文ID
- 130004431253
- 10030331986
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- NII書誌ID
- AA11010806
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- COI
- 1:CAS:528:DC%2BC38Xot1ensrk%3D
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- ISSN
- 13477501
- 13403516
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- NDL書誌ID
- 023538952
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可