Insulin Resistance and Metformin Treatment in Women with Polycystic Ovary Syndrome

• Matsuzaki Toshiya

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Iwasa Takeshi

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Matsui Sumika

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Kawami Takako

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Kato Takeshi

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Kuwahara Akira

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Munkhzaya Munkhsaihan

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Tungalagsuvd Altankhuu

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

• Irahara Minoru

  Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

抄録

Insulin resistance is one of the key factors in the pathogenesis of polycystic ovary syndrome (PCOS). Obesity, visceral fat accumulation and excessive serine phosphorylation of the insulin receptor are factors responsible for insulin resistance in PCOS. Insulin resistance induces compensatory hyperinsulinemia, which stimulates androgen synthesis in the theca cells of the PCOS ovary. Therefore, hyperinsulinemia results in hyperandrogenemia in PCOS patients who tend to have androgen-producing ovaries. In Japanese PCOS, 25% of patients are obese and 30% of patients have insulin resistance. Improvement of insulin resistance by weight loss, exercise and insulin sensitizing drugs such as metformin can recover reproductive function. Meformin has the potential to induce ovulation in PCOS, and 58% of clomiphene resistant Japanese PCOS patients resume ovulation after combined clomiphene metformin treatment. Clomiphene-metformin therapy is simple and has low risks of multiple pregnancy and ovarian hyperstimulation syndrome. Metformin use should be considered fertility treatment, especially as a second line therapy for the clomiphene resistant PCOS.

収録刊行物

• 日本哺乳動物卵子学会誌

  日本哺乳動物卵子学会誌 31 (1), 17-22, 2014

  日本卵子学会

キーワード

• pCOS
• Insulin resistance
• Hyperinsulinemia
• Metformin

詳細情報

• CRID: 1390001204338755200
• NII論文ID: 130004436878
• NII書誌ID: AN10548943
• DOI: 10.1274/jmor.31.17
• ISSN: 13475878
• ISSN: 13417738
• NDL書誌ID: 025509226
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025509226
• Web Site: https://search.jamas.or.jp/link/ui/2015077285
• 本文言語コード: en
• データソース種別:
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  • NDL
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  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可