Peroxisome Proliferator-activated Receptor-γ agonists Prevent Tumor Necrosis Factor-α-mediated Inhibition of FSH-induced Follicle Development and Estradiol Production in A PreantralFollicle Culture System

• Hara Shuichiro

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan Department of Obstetrics and Gynecology, Social Welfare Organization Saiseikai Imperial Gift Foundation Inc. Yamagata Saisei Hospital, 79-1, Okimachi, Yamagata city, Yamagata 990-8545, Japan

• Takahashi Toshifumi

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

• Igarashi Hideki

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

• Amita Mitsuyoshi

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

• Matsuo Koki

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

• Hasegawa Ayumi

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

• Kurachi Hirohisa

  Department of Obstetrics and Gynecology, Yamagata University Faculty of Medicine, Yamagata, 990-9585, Japan

抄録

Although 60–80% of the women with polycystic ovary syndrome (PCOS) ovulate with clomiphene citrate (CC), the rest are CC-resistant. Recently, the use of insulin-sensitizing agents such as metformin and pioglitazone have been proposed for inducing ovulation in CC-resistant women with PCOS, and we have reported that administration of bezafibrate, a lipid-lowering fibrate, in addition to CC, successfully induced ovulation in CC-resistant women with PCOS and dyslipidemia. Both pioglitazone and bezafibrate are peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists. This paper reviews the evidence for the direct effects of the drugs, which are PPAR-γ agonists, on follicle development and steroidogenesis, collected using an in vitro mouse preantral follicle culture system. We used the in vitro follicle culture system with the addition of tumor necrosis factor-alpha (TNF-α), which plays a role in insulin resistance, as a model for studying follicle development in women with PCOS. TNF-α inhibited FSH-induced follicle development and steroidogenesis in the follicle culture system. Both pioglitazone and bezafibrate prevented TNF-α-mediated inhibition of FSH-induced follicle development and steroidogenesis through the PPAR-γ-stimulating pathway. Our results suggest that insulin-sensitizing drugs, especially PPAR-γ agonists, may directly influence follicle development and steroidogenesis in women with PCOS.

収録刊行物

• 日本哺乳動物卵子学会誌

  日本哺乳動物卵子学会誌 31 (1), 2-11, 2014

  日本卵子学会

キーワード

• Polycystic ovary syndrome
• TNF-α
• PPAR-γ
• Pioglitazone
• Bezafibrate

詳細情報

• CRID: 1390282679315454592
• NII論文ID: 130004436884
• NII書誌ID: AN10548943
• DOI: 10.1274/jmor.31.2
• ISSN: 13475878
• ISSN: 13417738
• NDL書誌ID: 025509156
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025509156
• Web Site: https://search.jamas.or.jp/link/ui/2015077283
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可