Effects of Cholesterol-Lowering Therapy on Pressor Hyperreactivity to Stress in Hypercholesterolemic Patients

• MINAMI Mayumi

  Departments of Nephrology and Endocrinology University of Tokyo

• ATARASHI Keiichiro

  Departments of Nephrology and Endocrinology University of Tokyo

• ISHIYAMA Akihiro

  Departments of Nephrology and Endocrinology University of Tokyo

• HIRATA Yasunobu

  Cardiovascular Medicine, University of Tokyo

• GOTO Atsuo

  Departments of Nephrology and Endocrinology University of Tokyo

• OMATA Masao

  Gastroenterology, Faculty of Medicine, University of Tokyo

抄録

We previously demonstrated that normotensive patients with hypercholesterolemia showed excessive blood pressure (BP) responses to stress tests. In this study, we examined the effects of cholesterol-lowering therapy on BP in order to confirm that hypercholesterolemia plays a role in the regulation of BP. Fifteen patients with hypercholesterolemia and 24 normal cholesterolemic controls performed mental arithmetic stress (AS) and hand grip (HG) tests. BP was measured during the tests. Serum lipids and lipid peroxides were measured before the AS. Platelet intracellular free calcium concentration ([Ca²⁺])_i with and without low density lipoprotein (LDL) stimulation, plasma cGMP and NO_x were determined immediately before AS and at the end of each test. In hypercholesterolemic patients, the tests were repeated at the end of a 12-week treatment with 10 mg/day of pravastatin, a hepatic hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. In hypercholesterolemic patients, BP responses to both tests were greater than those of the controls. Basal and LDL-stimulated platelet [Ca²⁺]_i were higher, and the ratio of plasma cGMP to NO_x was lower. Serum total cholesterol, LDL cholesterol and lipid peroxides were significantly decreased in association with the pravastatin treatment. Systolic BP to AS and systolic BP/diastolic BP to HG were decreased (p <0.01, p <0.01/p <0.02, respectively). Platelet [Ca²⁺]_i with LDL stimulation was decreased (p <0.01). Plasma cGMP was increased (p <0.05), whereas NO_x was decreased (p <0.05); therefore, the ratio of cGMP to NO_x was increased (p <0.05). In conclusion, excessive blood pressure responses to stress tests were improved after cholesterol-lowering therapy. This finding suggests that hypercholesterolemia itself is involved in the regulation of BP. (Hypertens Res 2003; 26:273-280)

収録刊行物

• Hypertension Research

  Hypertension Research 26 (4), 273-280, 2003

  日本高血圧学会

キーワード

• <B>pressor hyperreactivity</B>
• <B>hypercholesterolemia</B>
• <B>cholesterol-lowering therapy</B>
• <B>platelet intracellular Ca<SUP>2+</SUP> concentration</B>
• <B>nitric oxide</B>

詳細情報

• CRID: 1390282679695713152
• NII論文ID: 130004437038
• NII論文ID: 30002004840
• NII論文ID: 50000826110
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.26.273
• COI: 1:CAS:528:DC%2BD3sXltlSnsbc%3D
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 12733694
• Web Site: https://search.jamas.or.jp/link/ui/2003274733
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可