A Case of Exercise-Induced Acute Renal Failure in a Patient with Idiopathic Renal Hypouricemia Developed during Antihypertensive Therapy with Losartan and Trichlormethiazide.

• ITO Osamu

  Department of Internal Medicine, Yamagata City Hospital Saiseikan

• HASEGAWA Yutaka

  Department of Internal Medicine, Yamagata City Hospital Saiseikan

• SATO Kazuto

  Department of Internal Medicine, Yamagata City Hospital Saiseikan

• MITSUI Hideaki

  Department of Radiology, Yamagata City Hospital Saiseikan

• YUDA Fumiaki

  Department of Pathology, Yamagata City Hospital Saiseikan

• SATO Hiroshi

  Department of Nephrology, Endocrinology and Hypertension, Tohoku University School of Medicine

• ITO Sadayoshi

  Department of Nephrology, Endocrinology and Hypertension, Tohoku University School of Medicine

• KUDO Ken-ichi

  Department of Internal Medicine, Yamagata City Hospital Saiseikan

抄録

Exercise-induced acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide. The antihypertensive therapy was stopped and marked hypouricemia became apparent during improvement of his renal function. The daily urinary excretion of uric acid was normal and an increased fractional excretion of uric acid was observed. Renal biopsy revealed that the kidney was recovering from acute tubular necrosis with interstitial fibrosis. Based on the results of pyrazinamide and benzbromarone tests, we classified this case as one of presecretory reabsorption defect of uric acid. Antihypertesive therapy with benidipine and candesartan was initiated, and the patient has not had any ARF episodes since. Because idiopathic renal hypouricemia can be associated with exercise-induced ARF and chronic renal dysfunction, careful antihypertensive therapy and follow-up evaluation of renal function might be necessary for hypertensive patients with idiopathic renal hypouricemia. (Hypertens Res 2003; 26: 509-513)

収録刊行物

• Hypertension Research

  Hypertension Research 26 (6), 509-513, 2003

  日本高血圧学会

キーワード

• <B>exercise-induced acute renal failure</B>
• <B>idiopathic renal hypouricemia</B>
• <B>urate transport</B>
• <B>hypertension</B>
• <B>losartan</B>

詳細情報

• CRID: 1390282679695970816
• NII論文ID: 130004437070
• NII論文ID: 50000867418
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.26.509
• COI: 1:STN:280:DC%2BD3szjt1SktQ%3D%3D
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 12862209
• Web Site: https://search.jamas.or.jp/link/ui/2003309126
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可