Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bg[J]/bg[J] (beige-J) Mice
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- Mori Tomohisa
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Funada Masahiko
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Tsuda Yuko
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Maeda Jun
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Uchida Masashi
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
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- Suzuki Tsutomu
- Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
書誌事項
- タイトル別名
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- Dopaminergic Hyperactivity Accompanied by Hyperlocomotion in C57BL/6J-bg<sup>J</sup>/bg<sup>J</sup> (beige-J) Mice
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抄録
Genetic factors affect locomotor activity, which mainly depends on the activation of dopaminergic systems. C57BL/6J-bgJbgJ (beige-J) mice, which exhibit deficiencies in immunological function, show behavioral hyperactivity. The present study was designed to investigate the locomotor activity of beige-J mice accompanied by a change in the dopaminergic system. Beige-J mice showed higher locomotor activity and dopamine turnover, whereas splenectomy reduced this hyperlocomotion and dopamine turnover. These results suggest that beige-J mice could be suitable as an experimental animal model for investigating hyperactivation of the dopaminergic system, and the spleen may contribute to the susceptibility of dopaminergic systems to activation.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 125 (2), 233-236, 2014
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155849216
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- NII論文ID
- 130004438633
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC2cXhtFaltb7J
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 025531468
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- PubMed
- 24881959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可