Current Perspective : Nicotine Effects and the Endogenous Opioid System

• Kishioka Shiroh

  Department of Pharmacology, Wakayama Medical University School of Medicine, Japan

• Kiguchi Norikazu

  Department of Pharmacology, Wakayama Medical University School of Medicine, Japan

• Kobayashi Yuka

  Department of Pharmacology, Wakayama Medical University School of Medicine, Japan

• Saika Fumihiro

  Department of Pharmacology, Wakayama Medical University School of Medicine, Japan

書誌事項

タイトル別名

• Nicotine Effects and the Endogenous Opioid System

抄録

Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins, and dynorphins) in the supraspinal cord. Additionally, systemic NIC administration induces the release of methionine-enkephalin in the spinal dorsal horn. NIC has acute neurophysiological actions, including antinociceptive effects, and the ability to activate the hypothalamic–pituitary-adrenal (HPA) axis. The endogenous opioid system participates in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception is mediated by α4β2 and α7 nAChRs, while NIC-induced HPA axis activation is mediated by α4β2, not α7, suggesting that the effects of NIC on the endogenous opioid system are mediated by α7, not α4β2. NIC has substantial physical dependence liability. The opioid-receptor antagonist naloxone (NLX) elicits NIC withdrawal after repeated NIC administration, and NLX-induced NIC withdrawal is inhibited by concomitant administration of an opioid-receptor antagonist. NLX-induced NIC withdrawal is also inhibited by concomitant administration of an α7 antagonist, but not an α4β2 antagonist. Taken together, these findings suggest that NIC-induced antinociception and the development of physical dependence are mediated by the endogenous opioid system, via the α7 nAChR.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 125 (2), 117-124, 2014

  公益社団法人 日本薬理学会

キーワード

• nicotine
• antinociception
• physical dependence
• <i>α</i>7 nAChR
• opioid system

詳細情報

• CRID: 1390282680155847680
• NII論文ID: 130004438636
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.14r03cp
• COI: 1:CAS:528:DC%2BC2cXhtFaltLfN
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 025531169
• PubMed: 24882143
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025531169
• Web Site: https://www.jstage.jst.go.jp/article/jphs/125/2/125_14R03CP/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015097629
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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