Flow-Injection Spectrophotometric Determination of Sulfadiazine and Sulfamethoxazole in Pharmaceuticals and Urine.

• FAN Jing

  School of Chemical & Environmental Sciences, Henan Normal University, Key Laboratory of Environmental Science and Engineering of Henan Education Commission

• CHEN Yahong

  School of Chemical & Environmental Sciences, Henan Normal University, Key Laboratory of Environmental Science and Engineering of Henan Education Commission

• FENG Suling

  School of Chemical & Environmental Sciences, Henan Normal University, Key Laboratory of Environmental Science and Engineering of Henan Education Commission

• YE Cunling

  School of Chemical & Environmental Sciences, Henan Normal University, Key Laboratory of Environmental Science and Engineering of Henan Education Commission

• WANG Jianji

  School of Chemical & Environmental Sciences, Henan Normal University, Key Laboratory of Environmental Science and Engineering of Henan Education Commission

抄録

A rapid and sensitive flow-injection spectrophotometric method is proposed for the determination of sulfadiazine and sulfamethoxazole. This method is based on the diazotization of sulfonamide with sodium nitrite, and a coupling reaction of the diazo-compound with α-naphthylamine. The optimum experimental conditions are obtained by using the controlled and weighted centroid simplex method. The linear ranges for the determination of sulfadiazine and sulfamethoxazole are 0.2 - 20 μg ml^-1 and 0.1 - 20 μg ml^-1 and their detection limits are 0.06 μg ml^-1 and 0.05 μg ml^-1, respectively, and the sampling frequency is 130 samples per hour. The method has been used to determine sulfadiazine and sulfamethoxazole in pharmaceuticals and urine without separation. The results are in agreement with those obtained by a high-performance liquid chromatograph technique at the 95% confidence level.

収録刊行物

• Analytical Sciences

  Analytical Sciences 19 (3), 419-422, 2003

  社団法人 日本分析化学会

キーワード

• Analytical Chemistry

詳細情報

• CRID: 1390282679235316096
• NII論文ID: 130004440723
• NII論文ID: 80015831093
• NII書誌ID: AA10500785
• DOI: 10.2116/analsci.19.419
• COI: 1:CAS:528:DC%2BD3sXisVaqsLY%3D
• ISSN: 13482246
• ISSN: 09106340
• NDL書誌ID: 6476098
• PubMed: 12675352
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6476098
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.19.419.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.19.419/fulltext.html
• Web Site: http://www.jstage.jst.go.jp/article/analsci/19/3/19_3_419/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可