Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering

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  • ZHANG Yan
    Hunan Xiangtan Institute for Food and Drug Control
  • HUANG Xiaoyan
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Central South University
  • LIU Wenfang
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Central South University
  • CHENG Zeneng
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Central South University
  • CHEN Chuanpin
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Central South University
  • YIN Lihui
    National Institutes for Food and Drug Control

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抄録

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 29 (10), 985-990, 2013

    社団法人 日本分析化学会

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