Immeasurably Low and Non-TRH-stimulatable TSH Associated with Normal I-123 Uptake in Two Goitrous Euthyroid Patients: Possible Existence of Other Thyroid-hormone Regulated Thyroid Stimulators other than TSH
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- IKEKUBO Katsuji
- Hyogo Health Service Association
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- HINO Megumu
- Department of Nuclear Medicine, Kobe City General Hospital
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- SAIKI Yasuhiko
- Department of Nuclear Medicine, Kobe City General Hospital
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- SON Cheol
- Department of Endocrinology, Kobe City General Hospital
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- IWAKURA Toshio
- Department of Endocrinology, Kobe City General Hospital
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- KOBAYASHI Hiromasa
- Department of Endocrinology, Kobe City General Hospital
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- ISHIHARA Takashi
- Department of Endocrinology, Kobe City General Hospital
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We described two euthyroid patients with normally functioning goiters, but with persistently undetectable and non-stimulatable TSH levels. Subject 1 was a 64-year-old woman with a large diffuse goiter who has been clinically and biochemically euthyroid without any medication for at least 19 years. Subject 2 was a 31-year-old woman with a small diffuse goiter who has been euthyroid for 4 years. Both patients had persistently undetectable levels of serum TSH, TSH receptor antibodies (TRAb) and thyroid stimulating antibodies (TSAb). Their basal TSH levels were very low and their T3 responses to TRH were very diminished or absent. In contrast, the basal levels of the other pituitary hormones and their responses to LHRH, GRH and CRH stimulation were all within normal limits in both patients. MRI images of pituitary glands, 123I thyroid uptake, and thyroid scans were normal. Ectopic thyroids were not detected on 99mTcO4– and 123I total body scans. Factors interfering with the measurement of TSH were excluded by recovery studies. In subject 1 a T3-suppression test was positive and a perchlorate discharge test was negative. In subject 2 a T3-suppression test was negative. Euthyroid Graves' disease, subclinical hyperthyroidism, destructive thyroiditis, thyrotoxicosis of extrathyroid origin, central hypothyroidism, and nonthyroidal illness were all ruled out by these observations. These results suggest that an unknown factor, such as thyrostimulin, but not TSH or TSAb, stimulates the thyroid and maintains euthyroidism, and may have a role in the regulation of the hypothalamus-pituitary-thyroid axis.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 52 (1), 61-68, 2005
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390001206299970176
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- NII論文ID
- 130004443152
- 10014483645
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- PubMed
- 15758559
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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