Severe Ascites with Hypothyroidism and Elevated CA125 Concentration: A Case Report

• KIMURA Ryosuke

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• IMAEDA Kenro

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• MIZUNO Tatsuo

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• WAKAMI Kazuko

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• YAMADA Kazuhiro

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• OKAYAMA Naotsuka

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• KAMIYA Yoshinobu

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

• JOH Takashi

  Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

抄録

Ascites caused by hypothyroidism is rare and the pathogenesis is unclear. Several reports have presented cases of progressive ascites with hypothyroidism and elevated tumor markers. We report a 31-year-old female case with massive ascites and elevated serum CA 125 concentrations. The patient had no typical feature of hypothyroidism except an accumulation of ascitic fluid which showed elevated total protein concentration and a high serum-ascites albumin gradient (SAAG). There was no finding of malignancy. Following thyroid hormone replacement, the ascites was completely resolved accompanied by reduced concentrations of serum CA125. In general, primary hypothyroidism with ascites presents with coexisting massive pericardial or pleural effusion. The massive ascites and increased serum CA125 concentrations may have led us to make the incorrect diagnosis of ovarian malignancy. The evaluation of thyroid function is useful to determine the pathology of high-protein ascites or elevated tumor markers, and ascites may be treatable by thyroid replacement therapy.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 54 (5), 751-755, 2007

  一般社団法人 日本内分泌学会

キーワード

• Myxedema
• Ascites
• TSBAb
• CA 125
• Hypothyroidism

詳細情報

• CRID: 1390282681275594240
• NII論文ID: 10020092958
• NII論文ID: 130004443313
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k06-139
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/54/5/54_K06-139/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008132060
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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