Hyponatremia is the valuable manifestation for initiating diagnosis of hypopituitarism in elderly

• Asano Tomoko

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Aoki Atsushi

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Sasaki Masami

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Ikoma Aki

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Kakei Masahumi

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Kawakami Masanobu

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

• Ishikawa San-e

  Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan

抄録

The present study was undertaken to determine clinical features of hypopituitarism in elderly subjects. Thirty-one elderly patients with hypopituitarism were enrolled. They were 19 males and 12 females, with the ages of 70.7±5.4 years ranging from 62 to 80 years. High prevalence of hyponatremia (80.6%) and hypoglycemia (29.0%) was found, and it was totally different from that in hypopituitarism from general population. There were two groups of hyponatremia derived from their clinical courses, namely, acute deterioration of hyponatremia and chronically persistent hyponatremia. Analysis for deficient hormones clearly showed that ACTH deficiency was highly found in 30 of 31 patients. There was no difference in serum cortisol levels between the hyponatremic and normonatremic patients. Despite hypoosmolality, plasma arginine vasopressin (AVP) was apparently high in the hyponatremic patients compared with in the normonatremic ones. The present study indicates that hyponatremia is the valuable finding for initiating diagnosis of hypopituitarism, and that augmented release of AVP may be involved in developing hyponatremia in elderly patients with hypopituitarism.

収録刊行物

• Endocrine Journal

  Endocrine Journal 59 (11), 1015-1020, 2012

  一般社団法人 日本内分泌学会

キーワード

• Pituitary-adrenal axis
• Arginine vasopressin
• Impaired water excretion

詳細情報

• CRID: 1390001206299865600
• NII論文ID: 10031146711
• NII論文ID: 130004443763
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.ej12-0067
• COI: 1:STN:280:DC%2BC38fksVOhtQ%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 22850090
• Web Site: https://www.jstage.jst.go.jp/article/endocrj/59/11/59_EJ12-0067/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013148944
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可