High Dietary n-6/n-3 PUFA Ratio Promotes HDL Cholesterol Level, but does not Suppress Atherogenesis in Apolipoprotein E-Null Mice 1

DOI 参考文献82件
  • Zhang Liang
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Geng Yue
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Xiao Ning
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Yin Miao
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Mao Liufeng
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Ren Guocheng
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Zhang Cong
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Liu Peng
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Lu Nannan
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • An Liguo
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University
  • Pan Jie
    The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences, Shandong Normal University

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Aim: Dietary fatty acids affect atherogenesis, which was presumed to be partly related to HDL cholesterol (HDL-C) metabolism. The major aim of the work was to analyze various ratios of n-6/n-3 PUFA diets on HDL-C metabolism in apolipoprotein E-null (apoE-/-) mice, which have similar symptoms to human type III familial hyperlipoproteinemia.<BR>Methods: Two-month-old male apoE-/- mice were fed four types of n-6/n-3 PUFA diet (group 1, 1.28; group 2, 5.03; group 3, 9.98 and group 4, 68.26) and control diet, respectively, for 6 weeks. With respect to serum apolipoprotein (apo) A-I concentration, lecithin-cholesterol acyltransferase (LCAT) activity and mRNA abundance of genes involved in HDL-C metabolism in the liver were analyzed.<BR>Results: Group 4 diet significantly increased the plasma HDL-C and apoA-I concentrations compared with other groups. LCAT activity in serum increased with decreased ratios of n-6/n-3 PUFA. As the dietary ratio of n-6/n-3 fatty acids increased, so did mRNA levels of hepatic apoA-I, scavenger receptor B class-1 (SR-B1), LCAT, ATP binding cassette transporter A1 (ABCA1), ABCG1 and liver X receptor alpha (LXRα). ApoA-II mRNA level, however, had a tendency to fall. Group 4 diet increased apoA-I and ABCA1 and decreased apoA-II transcriptional levels, whereas group 1 diet decreased mRNA levels of apoA-I, LCAT, SR-B1 and ABCG1.<BR>Conclusion: Our data indicated that a high ratio of n-6/n-3 PUFA increased the serum HDL-C level, but did not effectively suppress atherogenesis in apoE-/- mice. The elevated HDL-C level is possibly due to up-regulated hepatic apoA-I and ABCA1 with suppression of apoA-Ii expression.

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