Influence of Fatty Liver on Plasma Small, Dense LDL- Cholesterol in Subjects with and without Metabolic Syndrome

• Sugino Ikumi

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine.

• Kuboki Koji

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine.

• Matsumoto Tomoko

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine.

• Murakami Eiichi

  Laboratory Section of Toho University Omori Medical Center.

• Nishimura Chiaki

  Department of Medical Informatics, Toho University School of Medicine.

• Yoshino Gen

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine.

抄録

Aim: Small, dense low density lipoprotein (sLDL) is known as an atherogenic lipoprotein and is often associated with metabolic syndrome (MS). A high frequency of sLDL is found in hypertriglyceridemic subjects. Also, fatty liver (FL) is often associated with MS; therefore, we studied whether the association of FL increases sLDL- cholesterol (C ) in subjects with MS.<BR>Methods: In total, 207 patients were enrolled in this study and FL was estimated by echogram. The presence of MS was diagnosed according to the Japanese Guidelines for the Definition of Metabolic Syndrome.<BR>Results: sLDL-C and sLDL-C/LDL-C in the MS group were higher than in the non-MS group. Also, sLDL-C and sLDL-C/LDL-C in the FL group were higher than in the non-FL group. The simple correlation coefficient (r) between plasma triglyceride and sLDL-C or sLDL-C/LDL-C in all subjects was 0.36 and 0.51. In the MS group, r values were 0.32 and 0.52 while, in the non-FL group, r was 0.32 and 0.38, respectively. Two-way ANOVA revealed that FL was a powerful determinant of plasma sLDL-C and sLDL-C/LDL-C, but MS was not. When we divided all subjects into four groups, i.e., MS(-)FL(-), MS(-)FL(+), MS(+)FL(-) and MS(+)FL(+), sLDL-C/LDL-C of MS(+)FL(+) was significantly higher than all other groups.<BR>Conclusion: Association of MS and FL significantly increased sLDL-C and sLDL-C/LDL-C. The significant relationship between sLDL-C/LDL-C and plasma triglyceride in the FL group indicates that FL may produce triglyceriderich VLDL, a precurser of sLDL, thereby contributing to the appearance of sLDL particles in the plasma of MS patients with FL.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 18 (1), 1-7, 2011

  一般社団法人 日本動脈硬化学会

キーワード

• Small
• dense LDL(sLDL)
• Metabolic Syndrome(MS)
• Fatty Liver(FL)

詳細情報

• CRID: 1390001204432387200
• NII論文ID: 130004444464
• DOI: 10.5551/jat.5447
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2011303698
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可