Toxicogenomics/proteomics Report : Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney
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- Takahashi Yoshifumi
- Department of Dental Material Science, School of Dentistry, Aichi Gakuin University
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- Tsuruta Shozo
- Department of Dental Material Science, School of Dentistry, Aichi Gakuin University
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- Honda Akiko
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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- Fujiwara Yasuyuki
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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- Satoh Masahiko
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
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- Yasutake Akira
- Kumamoto University Graduate School of Science & Technology
書誌事項
- タイトル別名
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- Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney
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抄録
Dental amalgam is a source of exposure to elemental mercury vapor in the general population. The aim of this study was to elucidate the effect of elemental mercury vapor exposure from dental amalgam restorations on gene expression profiles. Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the cerebellum, increase the expression of 2 genes (Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
収録刊行物
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- The Journal of Toxicological Sciences
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The Journal of Toxicological Sciences 37 (3), 663-666, 2012
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282679881746688
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- NII論文ID
- 130004446987
- 10030436559
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- NII書誌ID
- AN00002808
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- COI
- 1:CAS:528:DC%2BC38XhtFajurjJ
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- ISSN
- 18803989
- 03881350
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- NDL書誌ID
- 023833784
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- PubMed
- 22688007
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可