Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

DOI Web Site Web Site PubMed 被引用文献4件 参考文献19件
  • Baba Hayato
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
  • Tsuneyama Koichi
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
  • Kumada Tokimasa
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
  • Aoshima Keiko
    Hagino Hospital
  • Imura Johji
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

この論文をさがす

抄録

Background & Aims Cadmium (Cd) is a widespread environmental contaminant that causes both renal tubulopathy and osteomalacia. Osteomalacia is thought to be a result of renal tubulopathy, but there are few studies about the histopathological relationship between the two pathoses. Therefore, in the present study, we examined specimens from cases of itai-itai disease (IID), the most severe form of chronic cadmium poisoning, to evaluate the relationship between them. Methods We analyzed kidney and bone specimens of 61 IID cases and the data regarding Cd concentration in kidney and bone. Tubulopathy was graded on the basis of a three-step scale (mild, moderate, and severe) using the following three items: the degree of proximal tubular defluxion, thickness of renal cortex, and weight of the kidney. Osteomalacia was evaluated using the relative osteoid volume (ROV). Results There were 15 cases of mild, 19 cases of moderate, and 27 cases of severe tubulopathy. The average ROV was 24.9 ± 2.0%. ROV tended to increase as tubulopathy advanced in severity, and ROV was significantly higher in cases with severe tubulopathy than those with mild or moderate tubulopathy. ROV had a negative correlation with Cd concentration in the kidney but no correlation with that in the bone. Conclusions Our results suggest that the development of osteomalacia was related to the development of tubulopathy.

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (19)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ