Symposium on 'Morphology and Physiology of Semicircular Canal Ampulla'. Neurotransmission in the vestibular endorgans. Glutamatergic transmission in the afferent synapses of hair cells.
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- Usami Shin-ichi
- Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621 Japan
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- Takumi Yutaka
- Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621 Japan
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- Matsubara Atsushi
- Department of Otorhinolaryngology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562 Japan
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- Fujita Shigetoshi
- Department of Otorhinolaryngology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562 Japan
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- Ottersen Ole P.
- Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, 0317 Oslo, Norway
書誌事項
- タイトル別名
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- Glutamatergic transmission in the afferent synapses of hair cells
抄録
In the sensory pathways the first synapse is that between hair cells and primary afferent neurons and its most likely neurotransmitter candidate has long been thought to be glutamate. A number of pharmacological and electrophysiological studies have lent credence to this theory (reviewed by Bledsoe et al. 1988, Bobbin 1979, Ehrenberger and Felix 1991, Puel et al. 1991; Puel 1995) as has recent neurochemical and immunocytochemical work (reviewed by Ottersen et al. 1998; Usami et al. 2000). These recent studies reveal that the afferent hair cell synapse resembles the central glutamate synapses in many ways. Of the proteins confirmed to be involved in signal transduction and transmitter metabolism at most central synapses, many are also seen in the afferent hair cell synapse, and have an analogous compartmentation. On the other hand, there are also important differences, especially those related to the molecular mechanisms that underlie transmitter release.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ ｉｎ Ｓｐａｃｅ
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Ｂｉｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ ｉｎ Ｓｐａｃｅ 15 (4), 367-370, 2001
日本宇宙生物科学会