Initial Attachment of Human Gingival Fibroblasts Derived from Diabetic Mellitus onto Collagen Coated Titanium

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  • FUSE Magumi
    Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo
  • HAYAKAWA Tohru
    Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo
  • TAKEUCHI Reiri
    Department of Oral Molecular Pharmacology, Nihon University School of Dentistry at Matsudo
  • NEBUKA Kenichi
    Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo
  • WAKAI Hiroaki
    Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo
  • FUKUMOTO Masahiko
    Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo
  • MAKIMURA Masaharu
    Department of Laboratory Medicine for Dentistry, Nihon University School of Dentistry at Matsudo

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Other Title
  • 糖尿病患者由来歯肉線維芽細胞のコラーゲンコートチタンへの初期付着について

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Abstract

Recently, diabetic mellitus is dramatically increasing in our country. A diabetic often induces the serious periodontal disease and following tooth lost. Therefore, there is a necessity for considering the cell activity to the implant materials for the diabetic mellitus. In the present study, we examined the initial cell attachment to titanium plate by using the human gingival fibrobrasts derived from diabetic mellitus patients. The influence of type I collagen coating on titanium plate for the enhancement of initial cell attachment was evaluated. As a result, collagen coating to titanium plate was effective for the improvement of initial cell attachment for non-diabetic mellitus. On the contrary, for human gingival cell derived from diabetic mellitus under the high blood glucose condition of HbA1c 9%, collagen coating to titanium plate was not effective for the enhancement of initial cell attachment.

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