Polymorphisms of Heme Oxygenase-1 and Bilirubin UDP-Glucuronosyltransferase Genes are not Associated with Kawasaki Disease Susceptibility
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- Kanai Masayo
- Department of Pediatrics, Yamagata University School of Medicine
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- Tanabe Saori
- Department of Pediatrics, Yamagata University School of Medicine
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- Okada Masahiko
- Department of Pediatrics, Yonezawa Municipal Hospital
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- Suzuki Hiroshi
- Department of Pediatrics, Yamagata University School of Medicine
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- Niki Takao
- Department of Pediatrics, Yamagata University School of Medicine
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- Katsuura Michihiko
- Department of Pediatrics, Yamagata Prefectural Kahoku Hospital
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- Akiba Tomoharu
- Department of Pediatrics, Saiseikan Yamagata Municipal Hospital
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- Hayasaka Kiyoshi
- Department of Pediatrics, Yonezawa Municipal Hospital
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抄録
Kawasaki disease (KD) is a systemic vasculitis and occurs among Japanese children at a high incidence. Serum bilirubin and heme oxygenase-1 (HO-1) expression are known to play a significant role in the protection of vascular endothelial cells. Japanese have unique polymorphic distribution patterns of (TA)7 or G71R of the bilirubin UDP-glucuronosyltransferase (B-UGT) gene and of (GT)n repeats of the HO-1 gene. We investigated the relationship of KD susceptibility with these polymorphisms. There were no significant differences in the distribution of allele frequencies and genotypes of these polymorphisms between KD patients and controls. These polymorphisms are not associated with KD susceptibility.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 200 (3), 155-159, 2003
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204240126592
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- NII論文ID
- 50000294038
- 130004459268
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- NII書誌ID
- AA00863920
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- COI
- 1:CAS:528:DC%2BD3sXot1Wjsb0%3D
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- ISSN
- 13493329
- 00408727
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- PubMed
- 14521259
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
