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- Lee Chien-Feng
- Department of Internal Medicine, Yuan's General Hospital, Taiwan
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- Sun Meng-Shun
- Department of Internal Medicine, Yuan's General Hospital, Taiwan
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- Tai Yen-Kuang
- Department of Internal Medicine, Yuan's General Hospital, Taiwan
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抄録
Although dipeptidyl peptidase-4 (DPP-4) inhibitors have been implicated in the development of acute pancreatitis, the causality of this phenomenon is not well established. We herein report the case of an 85-year-old woman who presented with epigastric pain after taking saxagliptin for five months. A high serum lipase level with characteristic computed tomography findings confirmed the diagnosis of acute pancreatitis. The patient's symptoms rapidly resolved after admission, although they recurred when she resumed treatment with saxagliptin for 18 days after discharge. In the absence of any identifiable causes of pancreatitis and considering the temporal sequence of events, the saxagliptin therapy was highly suspected to be the triggering factor. Although drug-induced pancreatitis is rare, treatment with DPP-4 inhibitors should be included as a potential etiology of acute pancreatitis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (12), 1351-1354, 2014
一般社団法人 日本内科学会